Interleukin-2-induced increase of a monoclonal b-cell lymphocytosis. A novel In vivo interleukin-2 effect?
نویسندگان
چکیده
منابع مشابه
Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells
B cells from patients suffering from B-type chronic lymphocytic leukemia (B-CLL) are susceptible to the effects of several interleukins. Using the cells from 12 different patients we show that IL-4 does not synergize with anti-mu antibody for the enhancement of DNA synthesis. Moreover IL-4 profoundly (90%) suppresses the response to IL-2 in the 10 patient responders to this interleukin. This su...
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Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...
متن کاملMonoclonal B-Cell Lymphocytosis
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 10(9)/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, cytopenias or autoimmune diseases. It is found in approximately 3-12% of normal persons depending on the accuracy of analytical techniques applied. According to the immunophenot...
متن کاملMonoclonal B-cell lymphocytosis☆
Chronic B-cell lymphocytic leukemia (B-CLL) represents 0.9% of all new cancers. It is estimated that there will be almost 15 000 new cases and 4600 deaths due to CLL in 2015 in the USA.1 The median ages at diagnosis and death are 71 years and 80 years, respectively.1 The criteria that define the diagnosis of B-CLL include the presence of at least 5 × 106 B lymphocytes/L with the peculiar CLL ph...
متن کاملMonoclonal B-cell lymphocytosis.
The incidence and presenting features of chronic lymphocytic leukemia (CLL) have changed significantly over the last century. Routine diagnostic techniques can now detect very low levels of CLL phenotype cells. Monoclonal B-cell lymphocytosis (MBL) is a relatively recent diagnostic category encapsulating individuals with an abnormal B-cell population but not meeting the diagnostic criteria for ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1992
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19920515)69:10<2583::aid-cncr2820691031>3.0.co;2-i